vivax (GenBank 5472322) into pHLsec mammalian expression vector. The construction of the chimeric (rPvCSP-c) protein comprised the clone DNA sequence in open reading frame of the central repeats from VK247 (GenBank P08677) and VK210 (GenBank M69059.1) isoforms, between N and C terminal regions from Salvador 1 strain of P. Since MCT exhibits the advantage of biodegradability over Alum, we wanted to explore its potential in non-allergy indications, and its applicability in infectious diseases, such as malaria as a suitable alternative biodegradable platform that could be translated across a broader vaccine scope.

MCT is used in combination with Monophosphoryl Lipid A (MPL ®) exclusively in allergy immunotherapy that offers shorter course therapy compared to conventional approaches, the observed immunological synergy and physicochemical compatibility in combining MCT with this Th1 adjuvant has been previously reported.

Moreover, it offers a compatible platform for the adsorption of a wide range of antigens and other immunomodulators to function as part of an adjuvant systems approach. The adjuvant mechanism of MCT is subject to ongoing studies, and has been reported to induce significant Th1 cytokine profiles and activation of specific signaling pathways. Its biodegradable nature results in total clearance at injection site (mitigating risk of granuloma formations)-while delivering a sustained release of antigens for prolonged immune exposure and, unlike alum, it is fully metabolized within the body. The proprietary platform exhibits distinct physicochemical properties, distinct mode of adsorption with antigens and an established stability profile, generates robust and sustained IgG antibodies titers with no unusual propensity to stimulate IgE. MCT has been used as a depot for a number of years with indications of its safe use and ability to enhance immune responses. Microcrystalline Tyrosine (MCT) was originally developed for use in allergen-specific immunotherapy (SIT) for the treatment of allergy.

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